WebIdarubicin HCl (4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl,Idamycin, Zavedos) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. Idarubicin induces mTOR-dependent cytotoxic autophagy. WebThe DNA topoisomerase drugs in current clinical use influence these enzymes in a very selective manner. These agents—including the eukaryotic DNA topoisomerase I drugs, …
Topoisomerase Topoisomerase I, II - Selleckchem.com
WebIdarubicin HCl (4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl,Idamycin, Zavedos) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA … WebNov 2, 2024 · Topoisomerase II. Topoisomerase II has the tricky job of untangling the coiled DNA and nicking both strands of DNA using its two sets of 'jaws.' These strong jaws cleave, or split, ... enlisted game theme song
Topoisomerase: Definition & Function - Study.com
WebJan 29, 2013 · Topoisomerase II DNA-gyrase during takes energy from ATP hydrolysis to introduce tight supercoils into the DNA helix with a view to condense the chromosome (chromosome condensation) Citation 16. 2.1. Eukaryotic topoisomerase. Eukaryotic topoisomerase are of two types: type I and type II Citation 17 . WebMar 4, 2024 · During mitosis, the DNA strands need to be free from interwinding which is done by topoisomerase I. Type II Topoisomerase Type II Topoisomerase Definition. … WebDec 10, 1996 · Type II topoisomerases are able to catalyze a number of reactions, including the relaxation of negative and positive supercoils, the catenation and decatenation of DNA circles, and the knotting and unknotting of DNA ().DNA gyrase is the only topoisomerase able to actively introduce negative supercoils into DNA molecules, in a reaction … dr fornecker angiologue haguenau