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High-Throughput Selectivity Assays for Small-Molecule Inhibitors …
WebApr 29, 2016 · Screening 2880 compounds with the assay enabled the identification of a new RNase P inhibitor. In another recent example, a FP assay was utilized to discover inhibitors for the cleavage of the human immunodeficiency virus (HIV) Gag protein into its two structural proteins, matrix (MA) and capsid (CA) . Instead of targeting the protease, … This technical note is designed to provide information to help the user define the optimal experimental conditions for converting existing assays to a robust fluorescence … See more 1.Maximize size differences between tracer and binder. When using a usual fluorophore such as fluorescein, Texas Red, Cy 5, BODIPY … See more 1.Estimate the best settings for your instrument. The following is a suggested starting point for instrument settings. Start with the PMT setting, … See more jonathan goldbloom montreal
UpToDate
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