Ezrin overexpression
WebJun 23, 2010 · Establishment of ezrin overexpression monoclones and silencing of the ezrin gene in MiaPaCa-2 cells. To study the function of the Vil2 gene in MiaPaCa-2 cells, the pcb6-ezrin-VSV-G vector was adopted to stably overexpress the ezrin protein, and the pcb6 vector was used as a control. For ezrin silencing, the three ezrin siRNAs, … WebOct 5, 2024 · Both ezrin activation and overexpression are closely correlated with the progression of different types of cancers that are associated with MCI misregulation . For example, high expression of ezrin and phosphorylation of ezrin at tyrosine 353 are significantly associated with lymph node metastasis and poor prognosis in colorectal …
Ezrin overexpression
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WebJul 9, 2024 · The direct regulatory relationship between miR211 and EZRIN was evaluated using dual-luciferase assay. The effect of miR211 and EZRIN overexpression on cell proliferation, migration/invasion, and apoptosis was detected. Results The expression of miR211 was obviously lower in osteosarcoma tissues than paracancerous tissues. WebFeb 1, 2024 · Both ezrin activation and overexpression are closely correlated with the progression of different types of cancers that are associated with MCI misregulation ( Table 1 ). For example, high expression of ezrin and phosphorylation of ezrin at tyrosine 353 are significantly associated with lymph node metastasis and poor prognosis in colorectal …
WebOverexpression of ezrin appeared to promote a subtle change in moesin distribution, from a preferentially basolateral distribution (Fig. 9 D) to a more diffuse cytoplasmic staining … WebFeb 1, 2015 · Ezrin overexpression is an independent prognostic factor in PDAC using the Cox proportional hazard regression model Using univariate analysis, we found that tumor size, lymph node metastasis, TNM stage, Ki-67 expression index, and ezrin expression were associated with overall survival rates.
WebApr 2, 2024 · Ezrin expression was upregulated in BC and correlated with a poor outcome To investigate the role of Ezrin in human BC, we first examined Ezrin expression in 117 pairs of BC and 47 normal breast tissues by IHC. The results revealed that Ezrin protein level was markedly upregulated in BC tissues (Fig. 1a, b ). WebFeb 16, 2024 · Ezrin is overexpressed in NSCLC patients and correlates with PD-L1 and YAP expression. Ezrin regulates YAP and PD-L1 expression. Inhibition of ezrin delayed NSCLC progression. To determine whether ezrin regulates Yes-associated protein (YAP) and programed cell death ligand-1 (PD-L1), which are involved in the invasion and metasta
WebJan 22, 2013 · Overexpression of B lymphoma Moloney murine leukemia virus insertion region-1 (BMI1), a transcription repressor that operates in stem cell maintenance and oncogenesis through inhibition of INK4A/ARF tumor suppressor locus, has been linked with increased incidence of metastasis in human gastric and breast cancer, as well as …
WebJun 29, 2010 · Ezrin overexpression was present in 38 cases (49%; Fig. 1d–f) and significantly more frequent in those myxofibrosarcomas that were remarkably necrotic (P … party hat image no backgroundWebMar 4, 2024 · Overexpression of Ezrin promoted myoblast differentiation/fusion, inducing increased MyHC-I+ and MyHC-II + muscle fiber specialization, and the specific effects … party hat image freeWebMar 23, 2024 · The overexpression of ezrin protein would promote the worsening of tumors . Several studies disclosed that ezrin proteins play an important role in the development of cancer ( 23 ). For example, in patients with osteosarcoma, ezrin protein expression level in vivo is higher than normal. party hat osrs geWebFeb 1, 2015 · The correlation between ezrin overexpression and the clinicopathological features of PDAC was evaluated using Chi-square test, and differences in survival … tincsWebJan 9, 2024 · Here, we found that overexpression of phosphorylated ezrin resulted in increased cell migration. This is consistent with previous studies showing that the invasive and metastatic ability of cancer cells is linked to high expression of phosphorylated ezrin [20,21]. We propose that overexpression of phosphorylated ezrin is associated with a ... party hat love movieWebAug 17, 2024 · Ezrin acts as a cross-linker between the cell membrane and the actin cytoskeleton. Ezrin is upregulated in various cancers and is associated with a poor prognosis (32, 33). Multiple studies have demonstrated that Ezrin overexpression in tumor cells increases their metastatic potential (19–22). Ezrin expression can be regulated by … tinc road schoolWebHere, we provide evidence that overexpression of ezrin, another closely related ezrin-radixin-moesin (ERM) family member, also blocks replication of both murine leukemia … party hat mockup free